Diclofenac Ophthalmic Solution
Jul 06, · Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body. Diclofenac ophthalmic (for the eye) is used to reduce swelling, pain, and light sensitivity after cataract surgery or corneal refractive surgery. Dec 28, · Diclofenac Sodium Ophthalmic is indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction and for the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery.
Medically reviewed by Carmen Fookes, BPharm. Last updated on Feb 21, If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:.
Note: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects.
View complete list of side effects. Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects. Medicines that interact with diclofenac may either decrease its what are the units used in measuring temperature, affect how long it works for, increase side effects, or have less of an effect when taken with diclofenac.
An interaction between two medications does not always mean that you must stop taking one of the medications; however, what is diclofenac sodium ophthalmic solution used for it does. Speak to your doctor about how drug interactions should be managed. Common medications that may interact with diclofenac include:. Drinking alcohol while taking diclofenac may increase the risk of gastrointestinal-related side effects or kidney damage.
Note that this list is not all-inclusive and includes only common medications that may interact with diclofenac. How to dissolve salicylic acid powder should refer to the prescribing information for diclofenac for a complete list of interactions. Carlsbad Technology, Inc. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use diclofenac only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Patient Tips diclofenac Print Share. How it works Diclofenac helps to relieve pain and inflammation by blocking the effects of cyclooxygenase COX enzymes.
This prevents prostaglandin synthesis prostaglandins elevate body temperature and make nerve endings more sensitive to pain transmission. Upsides Used to relieve mild-to-moderate acute pain associated with osteoarthritis and rheumatoid arthritis. May also be used to relieve mild-to-moderate pain due to other causes. Generic diclofenac is available. Downsides If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Stomach-related side effects such as indigestion, belching, heartburn, and bleeding.
People of an older age, taking other medicines that affect the stomach, or who drink more than 3 glasses of alcohol per day may be more at risk. Diclofenac is more likely than ibuprofen to cause stomach-related side effects. Water retention, headache, constipation, and nausea. Other side effects including tinnitus ringing in the ears have also been reported. Most NSAIDs have been associated with an increased risk of serious cardiovascular events including stroke or heart attack.
The risk may be higher in patients with pre-existing cardiovascular conditions and with higher dosages. May increase bleeding time especially if given with other medicines that also delay blood clotting.
May not be suitable for some people including those with kidney disease, a history of stomach ulcers or other gastrointestinal disorders, or with pre-existing cardiovascular disease. Should not be given during or following coronary artery bypass graft surgery. View complete list of side effects 4. Bottom Line Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects.
Tips Different formulations of diclofenac may not be equivalent; do not interchange products without first talking with your doctor or pharmacist. Should not be taken for for long periods of time, especially in seniors. Blood counts and liver enzymes may need monitoring periodically.
NSAIDs should not be used in the last 3 months of pregnancy; always ask your doctor before using any medication during pregnancy. If you have experienced asthma-like symptoms, developed hives urticaria or other allergic-type reactions in the past after taking aspirin or other NSAIDs like ibuprofendo not take diclofenac.
Combining diclofenac with alcohol may increase the risk of stomach ulcers or bleeding. Response and Effectiveness Time to peak effect varies from 30 minutes how to get songs off ipod hours depending on the formulation of diclofenac taken. Interactions Medicines that interact with diclofenac may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with diclofenac.
Common medications that may interact with diclofenac include: ACE inhibitors or ARBs, such as captopril, enalapril, or losartan Antibiotics, such as ciprofloxacin or vancomycin Anticoagulants blood thinners such as apixaban, dabigatran, fondaparinux, heparin, or warfarin Antidepressants, such as citalopram, escitalopram, fluoxetine, or paroxetine Antifungals, such as voriconazole Beta blockers, such as acebutolol, atenolol, bisoprolol, or carvedilol Bisphosphonates, such as alendronate Diuretics water pillssuch as chlorthalidone, chlorothiazide, or hydrochlorothiazide HIV medications eg, Stribild, tenofovir Other nonsteroidal anti-inflammatories NSAIDssuch as celecoxib, etodolac, ibuprofen, ketorolac, meloxicam, nabumetone, or naproxen Sulfonylureas a type of diabetes medicationsuch as glimepiride, glyburide, or glipizide Supplements, such as glucosamine, omega-3 fatty acids, vitamin E Others, such as cyclosporine, lithium, what is diclofenac sodium ophthalmic solution used for, pemetrexed, pirfenidone, or tacrolimus.
Drug Status Availability Prescription only What is diclofenac sodium ophthalmic solution used for. Lannett Company, Inc. Mylan Pharmaceuticals Inc. Sandoz Inc. Drug Class. Nonsteroidal anti-inflammatory drugs.
1. How it works
Uses This medication is used to treat swelling (inflammation) of the eye after cataract surgery. It is also used after another type of eye surgery (corneal refractive surgery) to temporarily. Diclofenac Sodium Ophthalmic is indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction and for the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery. Nov 03, · Voltaren Ophthalmic (diclofenac sodium) Solution % is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce swelling, pain, and light sensitivity after cataract surgery or corneal refractive surgery. Voltaren Ophthalmic is available in generic form.
Generic Name: diclofenac sodium Dosage Form: ophthalmic solution. Medically reviewed by Drugs. Last updated on Feb 1, Diclofenac Sodium Ophthalmic Solution, 0.
Diclofenac sodium is designated chemically as 2-[ 2,6-dichlorophenyl amino] benzeneacetic acid, monosodium salt, with an empirical formula of C 14 H 10 Cl 2 NO 2 Na. The structural formula of diclofenac sodium is:. Diclofenac Sodium Ophthalmic is available as a sterile solution, which contains diclofenac sodium 0.
Diclofenac sodium is a faintly yellow-white to light beige, slightly hygroscopic crystalline powder. It is freely soluble in methanol, sparingly soluble in water, very slightly soluble in acetonitrile, and insoluble in chloroform and in 0. Its molecular weight is Diclofenac Sodium Ophthalmic 0. Diclofenac Sodium Ophthalmic solution has a faint characteristic odor of castor oil.
Diclofenac sodium is one of a series of phenylacetic acids that has demonstrated anti-inflammatory and analgesic properties in pharmacological studies. It is thought to inhibit the enzyme cyclooxygenase, which is essential in the biosynthesis of prostaglandins. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
This study suggests that limited, if any, systemic absorption occurs with Diclofenac Sodium Ophthalmic. Postoperative Anti-Inflammatory Effects. In two double-masked, controlled, efficacy studies of postoperative inflammation, a total of cataract patients were treated with Diclofenac Sodium Ophthalmic and patients were treated with vehicle placebo.
Diclofenac Sodium Ophthalmic was favored over vehicle placebo over a 2-week period for the clinical assessments of inflammation as measured by anterior chamber cells and flare.
The efficacy of Diclofenac Sodium Ophthalmic given before and shortly after surgery was favored over vehicle placebo during the 6-hour period following surgery for the clinical assessments of pain and photophobia.
Patients were permitted to use a hydrogel soft contact lens with Diclofenac Sodium Ophthalmic for up to three days after PRK.
Diclofenac Sodium Ophthalmic is indicated for the treatment of postoperative inflammation in patients who have undergone cataract extraction and for the temporary relief of pain and photophobia in patients undergoing corneal refractive surgery. Diclofenac Sodium Ophthalmic is contraindicated in patients who are hypersensitive to any component of the medication. The refractive stability of patients undergoing corneal refractive procedures and treated with Diclofenac Sodium has not been established.
Patients should be monitored for a year following use in this setting. With some nonsteroidal anti-inflammatory drugs, there exists the potential for increased bleeding time due to interference with thrombocyte aggregation. There have been reports that ocularly applied nonsteroidal anti-inflammatory drugs may cause increased bleeding of ocular tissues including hyphemas in conjunction with ocular surgery.
There is the potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other nonsteroidal anti-inflammatory agents. Therefore, caution should be used when treating individuals who have previously exhibited sensitivities to these drugs. Topical corticosteroids are also known to slow or delay healing. Concomitant use of topical NSAIDs and topical steroids may increase the potential for healing problems.
In some susceptible patients continued use of topical NSAIDs may result in epithelial breakdown, corneal thinning, corneal infiltrates, corneal erosion, corneal ulceration, and corneal perforation. These events may be sight-threatening. Patients with evidence of corneal epithelial breakdown should immediately discontinue use of topical NSAIDs and should be closely monitored for corneal health. Postmarketing experience with topical NSAIDs suggests that patients experiencing complicated ocular surgeries, corneal denervation, corneal epithelial defects, diabetes mellitus, ocular surface disease e.
Postmarketing experience with topical NSAIDs also suggests that use more than 24 hours prior to surgery or use beyond 14 days post surgery may increase patient risk for occurrence and severity of corneal adverse events.
It is recommended that Diclofenac Sodium Ophthalmic, like other NSAIDs, be used with caution in patients with known bleeding tendencies or who are receiving other medications, which may prolong bleeding time. Use of the same bottle for both eyes is not recommended with topical eye drops that are used in association with surgery. Results from clinical studies indicate that Diclofenac Sodium Ophthalmic has no significant effect upon ocular pressure.
However, elevations in intraocular pressure may occur following cataract surgery. Except for the use of a bandage hydrogel soft contact lens during the first 3 days following refractive surgery, Diclofenac Sodium Ophthalmic should not be used by patients currently wearing soft contact lenses due to adverse events that have occurred in other circumstances.
Diclofenac Sodium did not show mutagenic potential in various mutagenicity studies including the Ames test. No overall differences in safety or effectiveness have been observed between elderly and younger adult patients. Pregnancy Category C. In rats, maternally toxic doses were associated with dystocia, prolonged gestation, reduced fetal weights and growth, and reduced fetal survival.
Diclofenac Sodium has been shown to cross the placental barrier in mice and rats. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Because of the known effects of prostaglandin biosynthesis inhibiting drugs on the fetal cardiovascular system closure of ductus arteriosus , the use of Diclofenac Sodium Ophthalmic during late pregnancy should be avoided.
It is not known whether topical ophthalmic administration of Diclofenac Sodium Ophthalmic could result in sufficient systemic absorption to produce detectable quantities in breast milk. Because many drugs are excreted in human milk, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. The following reactions have been identified during postmarketing use of topical Diclofenac Sodium Ophthalmic Solution, 0.
Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. The reactions, which have been chosen for inclusion due to either their seriousness, frequency of reporting, possible causal connection to topical Diclofenac Sodium Ophthalmic Solution, 0. Overdosage will not ordinarily cause acute problems. If Diclofenac Sodium Ophthalmic is accidentally ingested, fluids should be taken to dilute the medication.
One drop of Diclofenac Sodium Ophthalmic should be applied to the affected eye, 4 times daily beginning 24 hours after cataract surgery and continuing throughout the first 2 weeks of the postoperative period.
One or two drops of Diclofenac Sodium Ophthalmic should be applied to the operative eye within the hour prior to corneal refractive surgery. Within 15 minutes after surgery, one or two drops should be applied to the operative eye and continued 4 times daily for up to 3 days. The 2. To avoid contamination, dropper tip should not touch any surface.
Diclofenac Ophthalmic Solution. Drug Status Availability Prescription only Rx. Akorn, Inc. Sandoz Inc. Rising Pharmaceuticals, Inc. Drug Class. Ophthalmic anti-inflammatory agents. Related Drugs. Subscribe to our newsletters. FDA Safety Alerts for all medications. Daily MedNews.